diff --git a/e2e-tests/playwright/global_setup.ts b/e2e-tests/playwright/global_setup.ts
index 7bd53a3aa7..ea84873dda 100644
--- a/e2e-tests/playwright/global_setup.ts
+++ b/e2e-tests/playwright/global_setup.ts
@@ -2,7 +2,9 @@
 // See LICENSE.txt for license information.
 
 import {expect} from '@playwright/test';
+
 import {UserProfile} from '@mattermost/types/users';
+import { PreferenceType } from '@mattermost/types/preferences';
 
 import {Client, createRandomTeam, getAdminClient, getDefaultAdminUser, makeClient} from './support/server';
 import {defaultTeam} from './support/util';
@@ -63,6 +65,9 @@ async function sysadminSetup(client: Client, user: UserProfile | null) {
         );
     }
 
+    // Set default preferences
+    await savePreferences(client, user?.id ?? '');
+
     // Ensure all products as plugin are installed and active.
     await ensurePluginsLoaded(client);
 
@@ -184,4 +189,23 @@ async function ensureServerDeployment(client: Client) {
     }
 }
 
+async function savePreferences(client: Client, userId: UserProfile['id']) {
+    try {
+        if (!userId) {
+            throw new Error('userId is not defined');
+        }
+
+        const preferences: PreferenceType[] = [
+            {user_id: userId, category: 'tutorial_step', name: userId, value: '999'},
+            {user_id: userId, category: 'drafts', name: 'drafts_tour_tip_showed', value: JSON.stringify({drafts_tour_tip_showed: true})},
+            {user_id: userId, category: 'crt_thread_pane_step', name: userId, value: '999'},
+        ];
+        
+        await client.savePreferences(userId, preferences);
+    } catch (error) {
+        // eslint-disable-next-line no-console
+        console.log('Error saving preferences', error);
+    }
+}
+
 export default globalSetup;
diff --git a/e2e-tests/playwright/support/server/init.ts b/e2e-tests/playwright/support/server/init.ts
index 77cd701b6f..f48d59d94a 100644
--- a/e2e-tests/playwright/support/server/init.ts
+++ b/e2e-tests/playwright/support/server/init.ts
@@ -52,6 +52,8 @@ export async function initSetup({
         // Update user preference
         const preferences: PreferenceType[] = [
             {user_id: user.id, category: 'tutorial_step', name: user.id, value: '999'},
+            {user_id: user.id, category: 'drafts', name: 'drafts_tour_tip_showed', value: JSON.stringify({drafts_tour_tip_showed: true})},
+            {user_id: user.id, category: 'crt_thread_pane_step', name: user.id, value: '999'},
         ];
         await userClient.savePreferences(user.id, preferences);
 
diff --git a/e2e-tests/playwright/support/server/post.ts b/e2e-tests/playwright/support/server/post.ts
new file mode 100644
index 0000000000..514056fad4
--- /dev/null
+++ b/e2e-tests/playwright/support/server/post.ts
@@ -0,0 +1,32 @@
+// Copyright (c) 2015-present Mattermost, Inc. All Rights Reserved.
+// See LICENSE.txt for license information.
+
+import {Post, PostMetadata} from '@mattermost/types/posts';
+import {getRandomId} from '@e2e-support/util';
+
+export function createRandomPost(post?: Partial<Post>): Post {
+    if (post && post.channel_id && post.user_id) {
+        const time = Date.now();
+
+        const defaultPost = {
+            create_at: time,
+            user_id: post.user_id,
+            channel_id: post.channel_id,
+            root_id: post.root_id || '',
+            message: `${post?.message ?? ''}${getRandomId()}`,
+            pending_post_id: `${post.user_id}:${time}`,
+            props: post?.props || {},
+            file_ids: post?.file_ids || [],
+            metadata: {} as PostMetadata,
+        };
+
+        Reflect.deleteProperty(post, 'user_id');
+        Reflect.deleteProperty(post, 'channel_id');
+        Reflect.deleteProperty(post, 'message');
+        Reflect.deleteProperty(post, 'pending_post_id');
+
+        return {...defaultPost, ...post} as Post;
+    }
+
+    throw new Error('Post is missing channel_id or user_id or both');
+}
diff --git a/e2e-tests/playwright/support/ui/components/channels/delete_post_modal.ts b/e2e-tests/playwright/support/ui/components/channels/delete_post_modal.ts
new file mode 100644
index 0000000000..041f5a5afa
--- /dev/null
+++ b/e2e-tests/playwright/support/ui/components/channels/delete_post_modal.ts
@@ -0,0 +1,28 @@
+// Copyright (c) 2015-present Mattermost, Inc. All Rights Reserved.
+// See LICENSE.txt for license information.
+
+import {expect, Locator} from '@playwright/test';
+
+export default class DeletePostModal {
+    readonly container: Locator;
+    readonly confirmButton: Locator;
+
+    constructor(container: Locator) {
+        this.container = container;
+        this.confirmButton = this.container.locator('#deletePostModalButton');
+    }
+
+    async toBeVisible() {
+        await expect(this.container).toBeVisible();
+    }
+
+    async confirm() {
+        await this.confirmButton.waitFor();
+        await this.confirmButton.click();
+
+        // Wait for the modal to disappear
+        await expect(this.container).not.toBeVisible();
+    }
+}
+
+export {DeletePostModal};
diff --git a/e2e-tests/playwright/support/ui/components/channels/post.ts b/e2e-tests/playwright/support/ui/components/channels/post.ts
index 341571dd6d..94d0b87fbb 100644
--- a/e2e-tests/playwright/support/ui/components/channels/post.ts
+++ b/e2e-tests/playwright/support/ui/components/channels/post.ts
@@ -3,25 +3,43 @@
 
 import {expect, Locator} from '@playwright/test';
 
+import {components} from '@e2e-support/ui/components';
+
 export default class ChannelsPost {
     readonly container: Locator;
 
     readonly body;
     readonly profileIcon;
-    readonly replyButton;
+
+    readonly removePostButton;
+
+    readonly postMenu;
+    readonly threadFooter;
 
     constructor(container: Locator) {
         this.container = container;
 
         this.body = container.locator('.post__body');
+
         this.profileIcon = container.locator('.profile-icon');
-        this.replyButton = container.getByRole('button', {name: 'reply'});
+
+        this.removePostButton = container.locator('.post__remove');
+
+        this.postMenu = new components.PostMenu(container.locator('.post-menu'));
+        this.threadFooter = new components.ThreadFooter(container.locator('.ThreadFooter'));
     }
 
     async toBeVisible() {
         await expect(this.container).toBeVisible();
     }
 
+    /**
+     * Hover over the post. Can be used for post menu to appear.
+     */
+    async hover() {
+        await this.container.hover();
+    }
+
     async getId() {
         const id = await this.container.getAttribute('id');
         expect(id, 'No post ID found.').toBeTruthy();
@@ -29,13 +47,21 @@ export default class ChannelsPost {
     }
 
     async getProfileImage(username: string) {
-        return await this.profileIcon.getByAltText(`${username} profile image`);
+        return this.profileIcon.getByAltText(`${username} profile image`);
     }
 
-    async openRHS() {
+    /**
+     * Clicks on the deleted post's remove 'x' button.
+     * Also verifies that the post is a deleted post.
+     */
+    async remove() {
+        // Verify the post is a deleted post
+        await expect(this.container).toContainText(/\(message deleted\)/);
+
+        // Hover over the post and click on the remove post button
         await this.container.hover();
-        await this.replyButton.waitFor();
-        await this.replyButton.click();
+        await this.removePostButton.waitFor();
+        await this.removePostButton.click();
     }
 }
 
diff --git a/e2e-tests/playwright/support/ui/components/channels/post_create.ts b/e2e-tests/playwright/support/ui/components/channels/post_create.ts
index 912fcad80e..b43a213e91 100644
--- a/e2e-tests/playwright/support/ui/components/channels/post_create.ts
+++ b/e2e-tests/playwright/support/ui/components/channels/post_create.ts
@@ -9,7 +9,7 @@ export default class ChannelsPostCreate {
     readonly input;
     readonly attachmentButton;
     readonly emojiButton;
-    readonly sendButton: Locator;
+    readonly sendMessageButton;
 
     constructor(container: Locator) {
         this.container = container;
@@ -17,7 +17,7 @@ export default class ChannelsPostCreate {
         this.input = container.getByTestId('post_textbox');
         this.attachmentButton = container.getByLabel('attachment');
         this.emojiButton = container.getByLabel('select an emoji');
-        this.sendButton = container.getByTestId('SendMessageButton');
+        this.sendMessageButton = container.getByTestId('SendMessageButton');
     }
 
     async postMessage(message: string) {
@@ -25,7 +25,7 @@ export default class ChannelsPostCreate {
     }
 
     async sendMessage() {
-        await this.sendButton.click();
+        await this.sendMessageButton.click();
     }
 
     async toBeVisible() {
diff --git a/e2e-tests/playwright/support/ui/components/channels/post_dot_menu.ts b/e2e-tests/playwright/support/ui/components/channels/post_dot_menu.ts
new file mode 100644
index 0000000000..30e385f107
--- /dev/null
+++ b/e2e-tests/playwright/support/ui/components/channels/post_dot_menu.ts
@@ -0,0 +1,27 @@
+// Copyright (c) 2015-present Mattermost, Inc. All Rights Reserved.
+// See LICENSE.txt for license information.
+
+import {expect, Locator} from '@playwright/test';
+
+export default class PostDotMenu {
+    readonly container: Locator;
+
+    readonly deleteMenuItem;
+
+    constructor(container: Locator) {
+        this.container = container;
+
+        this.deleteMenuItem = this.container.getByText('Delete', {exact: true});   
+    }
+
+    async toBeVisible() {
+        await expect(this.container).toBeVisible();
+    }
+
+    async delete() {
+        await this.deleteMenuItem.waitFor();
+        await this.deleteMenuItem.click();
+    }
+}
+
+export {PostDotMenu};
diff --git a/e2e-tests/playwright/support/ui/components/channels/post_menu.ts b/e2e-tests/playwright/support/ui/components/channels/post_menu.ts
new file mode 100644
index 0000000000..ba97b07b66
--- /dev/null
+++ b/e2e-tests/playwright/support/ui/components/channels/post_menu.ts
@@ -0,0 +1,40 @@
+// Copyright (c) 2015-present Mattermost, Inc. All Rights Reserved.
+// See LICENSE.txt for license information.
+
+import {expect, Locator} from '@playwright/test';
+
+export default class PostMenu {
+    readonly container: Locator;
+
+    readonly replyButton;
+    readonly dotMenuButton;
+
+    constructor(container: Locator) {
+        this.container = container;
+
+        this.replyButton = container.getByRole('button', {name: 'reply'});
+        this.dotMenuButton = container.getByRole('button', {name: 'more'});
+    }
+
+    async toBeVisible() {
+        await expect(this.container).toBeVisible();
+    }
+
+    /**
+     * Clicks on the reply button from the post menu.
+     */
+    async reply() {
+        await this.replyButton.waitFor();
+        await this.replyButton.click();
+    }
+
+    /**
+     * Clicks on the dot menu button from the post menu.
+     */
+    async openDotMenu() {
+        await this.dotMenuButton.waitFor();
+        await this.dotMenuButton.click();
+    }
+}
+
+export {PostMenu};
diff --git a/e2e-tests/playwright/support/ui/components/channels/sidebar_left.ts b/e2e-tests/playwright/support/ui/components/channels/sidebar_left.ts
index ba75fa009d..eea28a0d35 100644
--- a/e2e-tests/playwright/support/ui/components/channels/sidebar_left.ts
+++ b/e2e-tests/playwright/support/ui/components/channels/sidebar_left.ts
@@ -16,6 +16,34 @@ export default class ChannelsSidebarLeft {
     async toBeVisible() {
         await expect(this.container).toBeVisible();
     }
+
+    /**
+     * Clicks on the sidebar channel link with the given name.
+     * It can be any sidebar item name including channels, direct messages, or group messages, threads, etc.
+     * @param channelName
+     */
+    async goToItem(channelName: string) {
+        const channel = this.container.locator(`#sidebarItem_${channelName}`);
+        await channel.waitFor();
+        await channel.click();
+    }
+
+    /**
+     * Verifies 'Drafts' as a sidebar link exists in LHS.
+     */
+    async draftsVisible() {
+        const draftSidebarLink = this.container.getByText('Drafts', {exact: true});
+        await draftSidebarLink.waitFor();
+        await expect(draftSidebarLink).toBeVisible();
+    }
+
+    /**
+     * Verifies 'Drafts' as a sidebar link does not exist in LHS.
+     */
+    async draftsNotVisible() {
+        const channel = this.container.getByText('Drafts', {exact: true});
+        await expect(channel).not.toBeVisible();
+    }
 }
 
 export {ChannelsSidebarLeft};
diff --git a/e2e-tests/playwright/support/ui/components/channels/sidebar_right.ts b/e2e-tests/playwright/support/ui/components/channels/sidebar_right.ts
index 76dd0cec54..852d94d6e1 100644
--- a/e2e-tests/playwright/support/ui/components/channels/sidebar_right.ts
+++ b/e2e-tests/playwright/support/ui/components/channels/sidebar_right.ts
@@ -3,16 +3,62 @@
 
 import {expect, Locator} from '@playwright/test';
 
+import {components} from '@e2e-support/ui/components';
+
 export default class ChannelsSidebarRight {
     readonly container: Locator;
 
+    readonly input;
+    readonly sendMessageButton;
+    readonly closeButton;
+
     constructor(container: Locator) {
         this.container = container;
+
+        this.input = container.getByTestId('reply_textbox');
+        this.sendMessageButton = container.getByTestId('SendMessageButton');
+
+        this.closeButton = container.locator('#rhsCloseButton');
     }
 
     async toBeVisible() {
         await expect(this.container).toBeVisible();
     }
+
+    async postMessage(message: string) {
+        await this.input.fill(message);
+    }
+
+    async sendMessage() {
+        await this.sendMessageButton.click();
+    }
+
+    /**
+     * Returns the value of the textbox in RHS
+     */
+    async getInputValue() {
+        return await this.input.inputValue();
+    }
+
+    /**
+     * Returns the RHS post by post id
+     * @param postId Just the ID without the prefix
+     */
+    async getRHSPostById(postId: string) {
+        const rhsPostId = `rhsPost_${postId}`;
+        const postLocator = this.container.locator(`#${rhsPostId}`);
+        return new components.ChannelsPost(postLocator);
+    }
+
+    /**
+     * Closes the RHS
+     */
+    async close() {
+        await this.closeButton.waitFor();
+        await this.closeButton.click();
+
+        await expect(this.container).not.toBeVisible();
+    }
 }
 
 export {ChannelsSidebarRight};
diff --git a/e2e-tests/playwright/support/ui/components/channels/thread_footer.ts b/e2e-tests/playwright/support/ui/components/channels/thread_footer.ts
new file mode 100644
index 0000000000..310aebe3d3
--- /dev/null
+++ b/e2e-tests/playwright/support/ui/components/channels/thread_footer.ts
@@ -0,0 +1,30 @@
+// Copyright (c) 2015-present Mattermost, Inc. All Rights Reserved.
+// See LICENSE.txt for license information.
+
+import {expect, Locator} from '@playwright/test';
+
+export default class ThreadFooter {
+    readonly container: Locator;
+
+    readonly replyButton: Locator;
+
+    constructor(container: Locator) {
+        this.container = container;
+
+        this.replyButton = container.locator('.ReplyButton');
+    }
+
+    async toBeVisible() {
+        await expect(this.container).toBeVisible();
+    }
+
+    /**
+     * Clicks on the reply button in the thread footer to open the thread in RHS.
+     */
+    async reply() {
+        await this.replyButton.waitFor();
+        await this.replyButton.click();
+    }
+}
+
+export {ThreadFooter};
diff --git a/e2e-tests/playwright/support/ui/components/index.ts b/e2e-tests/playwright/support/ui/components/index.ts
index 4aba6c2cd9..ebb3e3b879 100644
--- a/e2e-tests/playwright/support/ui/components/index.ts
+++ b/e2e-tests/playwright/support/ui/components/index.ts
@@ -11,6 +11,10 @@ import {ChannelsSidebarLeft} from './channels/sidebar_left';
 import {ChannelsSidebarRight} from './channels/sidebar_right';
 import {FindChannelsModal} from './channels/find_channels_modal';
 import {GlobalHeader} from './global_header';
+import {PostDotMenu} from './channels/post_dot_menu';
+import {DeletePostModal} from './channels/delete_post_modal';
+import {PostMenu} from './channels/post_menu';
+import {ThreadFooter} from './channels/thread_footer';
 
 const components = {
     BoardsSidebar,
@@ -23,6 +27,10 @@ const components = {
     ChannelsSidebarRight,
     FindChannelsModal,
     GlobalHeader,
+    PostDotMenu,
+    DeletePostModal,
+    PostMenu,
+    ThreadFooter,
 };
 
 export {
@@ -37,4 +45,8 @@ export {
     ChannelsSidebarRight,
     FindChannelsModal,
     GlobalHeader,
+    PostDotMenu,
+    DeletePostModal,
+    PostMenu,
+    ThreadFooter,
 };
diff --git a/e2e-tests/playwright/support/ui/pages/channels.ts b/e2e-tests/playwright/support/ui/pages/channels.ts
index 542f9a822d..5ec00ae40b 100644
--- a/e2e-tests/playwright/support/ui/pages/channels.ts
+++ b/e2e-tests/playwright/support/ui/pages/channels.ts
@@ -18,6 +18,8 @@ export default class ChannelsPage {
     readonly appBar;
     readonly sidebarLeft;
     readonly sidebarRight;
+    readonly postDotMenu;
+    readonly deletePostModal;
 
     constructor(page: Page) {
         this.page = page;
@@ -29,6 +31,8 @@ export default class ChannelsPage {
         this.appBar = new components.ChannelsAppBar(page.locator('.app-bar'));
         this.sidebarLeft = new components.ChannelsSidebarLeft(page.locator('#SidebarContainer'));
         this.sidebarRight = new components.ChannelsSidebarRight(page.locator('#sidebar-right'));
+        this.postDotMenu = new components.PostDotMenu(page.getByRole('menu', {name: 'Post extra options'}));
+        this.deletePostModal = new components.DeletePostModal(page.locator('#deletePostModal'));
     }
 
     async goto(teamName = '', channelName = '') {
diff --git a/e2e-tests/playwright/tests/functional/channels/drafts/drafts_on_deleted_message.spec.ts b/e2e-tests/playwright/tests/functional/channels/drafts/drafts_on_deleted_message.spec.ts
new file mode 100644
index 0000000000..3d61f80b07
--- /dev/null
+++ b/e2e-tests/playwright/tests/functional/channels/drafts/drafts_on_deleted_message.spec.ts
@@ -0,0 +1,132 @@
+// Copyright (c) 2015-present Mattermost, Inc. All Rights Reserved.
+// See LICENSE.txt for license information.
+
+import {test, expect} from '@e2e-support/test_fixture';
+import {createRandomPost} from '@e2e-support/server/post';
+
+test('MM-T5435_1 Global Drafts link in sidebar should be hidden when another user deleted root post and user removes the deleted post ', async ({
+    pw,
+    pages,
+}) => {
+    const {adminClient, team, adminUser, user} = await pw.initSetup();
+
+    if (!adminUser) {
+        throw new Error('Failed to create admin user');
+    }
+
+    // # Get the default channel of the team for getting the channel id
+    const channel = await adminClient.getChannelByName(team.id, 'town-square');
+
+    // # Create a post in the channel by admin
+    const adminPost = await adminClient.createPost(
+        createRandomPost({
+                channel_id: channel.id,
+                user_id: adminUser.id,
+        })
+    );
+
+    // # Log in as user in new browser context
+    const {page} = await pw.testBrowser.login(user);
+
+    // # Visit default channel page
+    const channelPage = new pages.ChannelsPage(page);
+    await channelPage.goto();
+    await channelPage.toBeVisible();
+
+    const lastPostByAdmin = await channelPage.getLastPost();
+    await lastPostByAdmin.toBeVisible();
+    
+    // # Open the last post sent by admin in RHS
+    await lastPostByAdmin.hover();
+    await lastPostByAdmin.postMenu.toBeVisible();
+    await lastPostByAdmin.postMenu.reply();
+
+    // # Write a message as a user
+    const sidebarRight = channelPage.sidebarRight;
+    await sidebarRight.toBeVisible();
+    await sidebarRight.postMessage('Replying to a thread');
+    await sidebarRight.sendMessage();
+
+    // # Write a message in the reply thread but don't send it now so that it becomes a draft
+    const draftMessageByUser = 'I should be in drafts by User';
+    await sidebarRight.postMessage(draftMessageByUser);
+
+    // # Close the RHS for draft to be saved
+    await sidebarRight.close()
+
+    // * Verify drafts link in channel sidebar is visible
+    await channelPage.sidebarLeft.draftsVisible();
+
+    // # Delete the last post by admin
+    try {
+        await adminClient.deletePost(adminPost.id);
+    } catch (error) {
+        throw new Error('Failed to delete post by admin');
+    }
+
+    // # Open the last post in the channel sent by admin again
+    await lastPostByAdmin.threadFooter.reply();
+
+    // * Verify drafts in user's textbox is still visible
+    const rhsTextboxValue = await sidebarRight.getInputValue();
+    expect(rhsTextboxValue).toBe(draftMessageByUser);
+
+    // # Click on remove post
+    const deletedPostByAdminInRHS = await sidebarRight.getRHSPostById(adminPost.id);
+    await deletedPostByAdminInRHS.remove();
+
+    // * Verify the drafts links should also be removed from sidebar
+    await channelPage.sidebarLeft.draftsNotVisible();
+});
+
+test('MM-T5435_2 Global Drafts link in sidebar should be hidden when user deletes root post ', async ({pw, pages}) => {
+    const {user} = await pw.initSetup();
+
+    // # Log in as user in new browser context
+    const {page} = await pw.testBrowser.login(user);
+
+    // # Visit default channel page
+    const channelPage = new pages.ChannelsPage(page);
+    await channelPage.goto();
+    await channelPage.toBeVisible();
+
+    // # Post a message in the channel
+    await channelPage.postMessage('Message which will be deleted');
+    await channelPage.sendMessage();
+
+    // # Start a thread by clicking on reply menuitem from post options menu
+    const post = await channelPage.getLastPost();
+    await post.hover();
+    await post.postMenu.toBeVisible();
+    await post.postMenu.reply();
+
+    const sidebarRight = channelPage.sidebarRight;
+    await sidebarRight.toBeVisible();
+
+    // # Write a message in the thread
+    await sidebarRight.postMessage('Replying to a thread');
+    await sidebarRight.sendMessage();
+
+    // # Write a message in the reply thread but don't send it
+    await sidebarRight.postMessage('I should be in drafts');
+
+    // # Close the RHS for draft to be saved
+    await sidebarRight.close()
+
+    // * Verify drafts link in channel sidebar is visible
+    await channelPage.sidebarLeft.draftsVisible();
+
+    // # Click on the dot menu of the post and select delete
+    await post.hover();
+    await post.postMenu.toBeVisible();
+    await post.postMenu.openDotMenu();
+    await channelPage.postDotMenu.toBeVisible()
+    await channelPage.postDotMenu.delete();
+
+    // # Confirm the delete from the modal
+    await channelPage.deletePostModal.toBeVisible();
+    await channelPage.deletePostModal.confirm();
+
+    // * Verify drafts link in channel sidebar is visible
+    await channelPage.sidebarLeft.draftsNotVisible();
+});